Phenotypes associated with this allele

• Allele Symbol: Tle5^tm1.1Mmt
• Allele Name: targeted mutation 1.1, Makoto M Taketo
• Allele ID: MGI:4888012
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tle5^tm1.1Mmt/Tle5^tm1.1Mmt Apc^tm1Mmt/Apc^+ Tg(Vil1-cre/ERT2)23Syr/0	involves: 129S2/SvPas * C57BL/6 * DBA * SJL	MGI:4888016

Genotype
MGI:4888016

cn1

• Allelic Composition: Tle5^tm1.1Mmt/Tle5^tm1.1Mmt; Apc^tm1Mmt/Apc⁺; Tg(Vil1-cre/ERT2)23Syr/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased colon adenocarcinoma incidence ( J:168065 )

• adenocarcinomas by histopathological definition

• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apc^tm1Mmt adenomas, without a very malignant appearance

increased small intestine adenocarcinoma incidence ( J:168065 )

• adenocarcinomas by histopathological definition

• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apc^tm1Mmt adenomas, without a very malignant appearance

increased metastatic potential ( J:168065 )

• treated with 4-hydroxytamoxifen to activate Cre recombinase at 3 weeks of age

• tumor invasion and intravasation into the smooth muscle layer of the small intestine and colon at 17 weeks of age

• in polyps larger than 2 mm in diameter, about half of them is found invading into the submucosa or beyond

• often seen inside vessels that are distended, reminiscent of tumor embolism

digestive/alimentary system

increased colon adenocarcinoma incidence ( J:168065 )

• adenocarcinomas by histopathological definition

• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apc^tm1Mmt adenomas, without a very malignant appearance

increased small intestine adenocarcinoma incidence ( J:168065 )

• adenocarcinomas by histopathological definition

• the extent of cellular atypia and epithelial architecture are rather similar to those in the Apc^tm1Mmt adenomas, without a very malignant appearance