homeostasis/metabolism
• in mice fed a high-fat diet
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• mice exhibit increased hepatic glucose turnover at rest compared with wild-type mice
• however, insulin sensitivity under hyperinsulinemic conditions is normal
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• at 4 weeks and further at 12 weeks, when fed a high-fat diet
• pre- and post-high-fat diet
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• basal concentrations of insulin are increased compared to in wild-type mice
• however, insulin levels are normal after glucose stimulation
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• in fasted and fed states
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• when fed a high-fat diet, resting metabolic rate is decreased compared to in wild-type mice
• however, the respiratory exchange ratio is normal
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muscle
• in fed and fasted states
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• in fed and fasted states
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growth/size/body
• by weaning until 16 weeks of age and while being fed a high-fat diet
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• in a fasted state
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behavior/neurological
• at 7 to 10 weeks and 12 weeks of age when fed a high-fat diet
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adipose tissue
• in a fed state
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liver/biliary system
• in a fasted state
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limbs/digits/tail
• in fed and fasted states
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• in fed and fasted states
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