Analysis Tools
mortality/aging
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• die between E11.5 and E13.5
|
embryo
|
• at E8.0
|
|
• at E9.5
|
|
• absence of V3 interneural cells in the rostral neural tube at the forelimb level at E10.5
• motor neurons expand ventrally and laterally in neural tubes at E10.5
|
nervous system
|
• absence of V3 interneural cells in the rostral neural tube at the forelimb level at E10.5
• motor neurons expand ventrally and laterally in neural tubes at E10.5
|
exencephaly
(
J:143544
)
|
• motor neurons expand ventrally and laterally in neural tubes at E10.5
|
|
• absence of V3 interneural cells in the rostral neural tube at the forelimb level at E10.5
|
vision/eye
cardiovascular system
|
• in some embryos
|
hemorrhage
(
J:143544
)
|
• diffuse hemorrhagic lesions
|
growth/size/body
|
• in some embryos
|
|
• defect in wall closure
|
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• defects in the ventral region of the head
|
|
• neck region appears elongated at E9.5
|
|
• in some embryos
|
limbs/digits/tail
ectrodactyly
(
J:143544
)
|
• fusion of supernumerary digits at E12.5
|
|
• expression analysis indicates defects in patterning at E10.5
|
|
• delay in limb outgrowth
|
cellular
|
• serum starved MEFs fail to form cilia
|
|
• at E8.0
|
digestive/alimentary system
|
• in some embryos
|
