Phenotypes associated with this allele

• Allele Symbol: Slco2a1^tm1.2Vsch
• Allele Name: targeted mutation 1.2, Victor L Schuster
• Allele ID: MGI:4888397
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slco2a1^tm1.2Vsch/Slco2a1^tm1.2Vsch	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N	MGI:4888412

Genotype
MGI:4888412

hm1

• Allelic Composition: Slco2a1^tm1.2Vsch/Slco2a1^tm1.2Vsch
• Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:168442 )

• no mice survive beyond P1

• however, indomethacin-treatment rescues neonatal survival

cardiovascular system

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth

dilated heart left ventricle ( J:168442 )

• in mice that die on P1

dilated heart right ventricle ( J:168442 )

• in mice that die on P1

homeostasis/metabolism

abnormal prostaglandin level ( J:168442 )

• indomethacin-rescued mice exhibit reduced prostaglandin E2 metabolite plasma concentrations compared with wild-type mice

• mice from maternal indomethacin rescue exhibit increased urinary prostaglandin E2 levels compared with wild-type mice

abnormal urine homeostasis ( J:168442 )

• mice from maternal indomethacin rescue exhibit increased urinary prostaglandin E2 levels compared with wild-type mice

cellular

abnormal cell physiology ( J:168442 )

• mouse embryonic fibroblasts fail to exhibit carrier-mediated 3H-PGE2 uptake unlike wild-type cells

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth

renal/urinary system

abnormal urine homeostasis ( J:168442 )

• mice from maternal indomethacin rescue exhibit increased urinary prostaglandin E2 levels compared with wild-type mice