All Phenotypes Slco2a1<tm1Vsch> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slco2a1^tm1Vsch
targeted mutation 1, Victor L Schuster
MGI:4888398

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slco2a1^tm1Vsch/Slco2a1^tm1Vsch	involves: 129S6/SvEvTac * C57BL/6J	MGI:4888411

Allelic Composition	Slco2a1^tm1Vsch/Slco2a1^tm1Vsch
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slco2a1^tm1Vsch mutation (0 available); any Slco2a1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:168442 )

• no mice survive beyond P2

cardiovascular system

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth

dilated heart left ventricle ( J:168442 )

• in mice that die on P1

dilated heart right ventricle ( J:168442 )

• in mice that die on P1

cellular

patent ductus arteriosus ( J:168442 )

• after birth, the ductus arteriosus exhibits a single endothelial layer with an open lumen covered by layers of normal intimal thickening unlike in wild-type mice

• however, the ductus arteriosus is normal before birth

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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