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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fasltm1.1Cgm
targeted mutation 1.1, Geert Michel
MGI:4888490
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fasltm1.1Cgm/Fasltm1.1Cgm involves: 129S2/SvPas * C57BL/6 * C57BL/6N MGI:4888492


Genotype
MGI:4888492
hm1
Allelic
Composition		 Fasltm1.1Cgm/Fasltm1.1Cgm
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fasltm1.1Cgm mutation (1 available); any Fasl mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:168406 )
N
• lymphocytes exhibit normal induced apoptosis
increased B cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice
increased T cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice
increased germinal center B cell number ( J:168406 )
• following stimulation with NP-CGG
increased plasma cell number ( J:168406 )
• following stimulation with NP-CGG or NP-Ficoll
increased IgM level ( J:168406 )
• following stimulation with NP-CGG or NP-Ficoll

hematopoietic system
increased B cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice
increased T cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice
increased germinal center B cell number ( J:168406 )
• following stimulation with NP-CGG
increased plasma cell number ( J:168406 )
• following stimulation with NP-CGG or NP-Ficoll
increased IgM level ( J:168406 )
• following stimulation with NP-CGG or NP-Ficoll

cellular
increased B cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice
increased T cell proliferation ( J:168406 )
• activation-induced lymphocyte proliferation is increased compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory