Phenotypes associated with this allele

• Allele Symbol: Tg(CSN2-fat-1)1Vane
• Allele Name: transgene insertion 1, Alison Van Eenennaam
• Allele ID: MGI:4888569
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CSN2-fat-1)1Vane/0	involves: C57BL/6 * DBA	MGI:5013405

Genotype
MGI:5013405

tg1

• Allelic Composition: Tg(CSN2-fat-1)1Vane/0
• Genetic Background: involves: C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal milk composition ( J:168456 )

♀ • proportions of n-6 linoleic acid and arachidonic acid are decreased in the phospholipid fraction of milk from transgenic females

♀ • linoleic acid fraction is increased in the triacylglyceride fraction

♀ • proportions of n-3 alpha linoleic acid and eicosapentaenoic acid are increased in both the triacylglyceride and phospholipid fractions

♀ • n-6:n-3 ratio of fatty acids in milk phospholipids is increased as compared to controls (9.82 and 1.78, respectively)

homeostasis/metabolism

decreased unsaturated fatty acids level ( J:168456 )

• proportions of n-6 linoleic acid and arachidonic acid are decreased in the phospholipid fraction of milk from transgenic females

• arachidonic acid and n-6 docosapentaenoic acid levels are decreased in the brains of 15 day old pups nursed by transgenic females

increased unsaturated fatty acids level ( J:168456 )

• proportions of n-3 alpha linoleic acid and eicosapentaenoic acid are increased in both the triacylglyceride and phospholipid fractions of milk from transgenic females

• linoleic acid fraction is increased in the triacylglyceride fraction of milk from transgenic females

• linoleic acid, alpha linoleic acid, eicosapentaenoic acid and n-3 docosapentaenoic acid levels are increased in the brains of 15 day old pups nursed by transgenic females

integument

abnormal milk composition ( J:168456 )

♀ • proportions of n-6 linoleic acid and arachidonic acid are decreased in the phospholipid fraction of milk from transgenic females

♀ • linoleic acid fraction is increased in the triacylglyceride fraction

♀ • proportions of n-3 alpha linoleic acid and eicosapentaenoic acid are increased in both the triacylglyceride and phospholipid fractions

♀ • n-6:n-3 ratio of fatty acids in milk phospholipids is increased as compared to controls (9.82 and 1.78, respectively)