Phenotypes associated with this allele

• Allele Symbol: Itgal^tm1.1Mshi
• Allele Name: targeted mutation 1.1, Motomu Shimaoka
• Allele ID: MGI:4888587
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgal^tm1.1Mshi/Itgal^tm1.1Mshi	involves: C57BL/6	MGI:4888702

Genotype
MGI:4888702

hm1

• Allelic Composition: Itgal^tm1.1Mshi/Itgal^tm1.1Mshi
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal leukocyte migration ( J:168533 )

• T cell homing to peripheral and mesenteric lymph nodes are reduced compared to in wild-type mice

• T cells exhibit abnormal intravascular crawling and diapedesis compared with wild-type cells

• however, T cell interstitial motility is normal

abnormal diapedesis ( J:168533 )

• T cells exhibit abnormal diapedesis compared with wild-type cells

abnormal leukocyte adhesion ( J:168533 )

• lymphocytes exhibit increased binding to ICAM1 and decreased transmigration in a Transwell assay across ICAM1-coated inserts compared with wild-type mice

enhanced leukocyte tethering or rolling ( J:168533 )

• T cell rolling velocity on high-order venules is slower than wild-type cells

decreased lymphocyte cell number ( J:168533 )

• in peripheral lymph nodes

small lymph nodes ( J:168533 )

• peripheral lymph nodes are smaller than in wild-type mice

hematopoietic system

abnormal leukocyte migration ( J:168533 )

• T cell homing to peripheral and mesenteric lymph nodes are reduced compared to in wild-type mice

• T cells exhibit abnormal intravascular crawling and diapedesis compared with wild-type cells

• however, T cell interstitial motility is normal

abnormal diapedesis ( J:168533 )

• T cells exhibit abnormal diapedesis compared with wild-type cells

abnormal leukocyte adhesion ( J:168533 )

• lymphocytes exhibit increased binding to ICAM1 and decreased transmigration in a Transwell assay across ICAM1-coated inserts compared with wild-type mice

enhanced leukocyte tethering or rolling ( J:168533 )

• T cell rolling velocity on high-order venules is slower than wild-type cells

decreased lymphocyte cell number ( J:168533 )

• in peripheral lymph nodes

cellular

abnormal leukocyte migration ( J:168533 )

• T cell homing to peripheral and mesenteric lymph nodes are reduced compared to in wild-type mice

• T cells exhibit abnormal intravascular crawling and diapedesis compared with wild-type cells

• however, T cell interstitial motility is normal

abnormal diapedesis ( J:168533 )

• T cells exhibit abnormal diapedesis compared with wild-type cells

abnormal leukocyte adhesion ( J:168533 )

• lymphocytes exhibit increased binding to ICAM1 and decreased transmigration in a Transwell assay across ICAM1-coated inserts compared with wild-type mice

enhanced leukocyte tethering or rolling ( J:168533 )

• T cell rolling velocity on high-order venules is slower than wild-type cells