Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Mbp-MAPT/lacZ)#aCaw transgene insertion #a, Christopher A Walsh MGI:4888711 |
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| Summary |
9 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
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• thalamocortical axons fail to extend beneath the cortical plate and grow obliquely across it unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within a few hours of birth
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• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
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• small and misshapen
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• small and misshapen
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• thalamocortical axons exhibit severe ventral misrouting near the diencephalon-telencephalon boundary on the ventral surface compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal thalamocortical axons
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• slightly small
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• slightly small
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• slightly small
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• in some mice
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• in some mice
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• in 38 of 46 mice
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• in 38 of 46 mice
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• in 10 of 42 mice
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• in 13% of mice
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• in 10 of 42 mice
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• mice exhibit occasional ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• in 10 of 42 mice
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• small head
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
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• the forebrain has a cobblestone surface unlike in wild-type mice
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• stunted
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• thalamocortical axons exhibit fascicles to ectopia outside pia unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants collected after birth died within hours (100%; 15 of 15)
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• the intermediate zone contains large swollen bundles of axon compared with wild-type mice
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• round
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• slightly small
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• slightly small
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• the thalamocortical axons are disorganized in the ventral telencephalon with some stalled at the corticostriatal boundary unlike in wild-type mice
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• some thalamocortical axons are overfasciculated and stalling compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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• some mice exhibit ventral misrouting of thalamocortical axons in the ventral telencephalon compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
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• thalamocortical axons exhibit overfasciculation and stalling compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable and fertile, with no detectable abnormal phenotypes in brain morphology or thalamacortical axon patterning at birth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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