Phenotypes associated with this allele

• Allele Symbol: Crisp2^{tm1a(KOMP)Mbp}
• Allele Name: targeted mutation 1a, Mouse Biology Program, UC Davis
• Allele ID: MGI:4888856
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crisp2^tm1a(KOMP)Mbp/Crisp2^tm1a(KOMP)Mbp	C57BL/6N-Crisp2^tm1a(KOMP)Mbp	MGI:6369094

Genotype
MGI:6369094

hm1

• Allelic Composition: Crisp2^{tm1a(KOMP)Mbp}/Crisp2^{tm1a(KOMP)Mbp}
• Genetic Background: C57BL/6N-Crisp2^{tm1a(KOMP)Mbp}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:273472 )

♀N • female fertility is similar to controls

abnormal sperm motility ( J:273472 )

♂ • in many sperm the distal part of the midpiece is stiff resulting in an abnormal beating pattern

decreased sperm progressive motility ( J:273472 )

♂ • reduction in total motility correlates to a reduction in the percentage of sperm displaying progressive motility

♂ • significant reduction in the percentage of sperm displaying rapid forms of progressive motility

asthenozoospermia ( J:273472 )

♂ • show a 16.1% reduction in the number of sperm showing any form of motility

reduced male fertility ( J:273472 )

♂ • males are sub-fertile

♂ • however, testes weight and sperm production and histology are similar to controls

impaired acrosome reaction ( J:273472 )

♂ • decrease in the percentage of sperm that undergo progesterone-evoked acrosome reaction

♂ • percentage of sperm undergoing acrosome reaction correlates with residual gene expression

cellular

abnormal sperm motility ( J:273472 )

♂ • in many sperm the distal part of the midpiece is stiff resulting in an abnormal beating pattern

decreased sperm progressive motility ( J:273472 )

♂ • reduction in total motility correlates to a reduction in the percentage of sperm displaying progressive motility

♂ • significant reduction in the percentage of sperm displaying rapid forms of progressive motility

asthenozoospermia ( J:273472 )

♂ • show a 16.1% reduction in the number of sperm showing any form of motility