Phenotypes associated with this allele

• Allele Symbol: Hdac3^tm1.1Laz
• Allele Name: targeted mutation 1.1, Mitchell A Lazar
• Allele ID: MGI:4889069
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz	C57BL/6-Hdac3^tm1.1Laz	MGI:4889070
cn2	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz	involves: C57BL/6	MGI:5575517
cn3	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz Tg(Fabp4-cre)1Rev/0	involves: C57BL/6	MGI:5515397
cn4	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz Tg(Retn-cre)1Laz/0	involves: C57BL/6	MGI:5515396
cn5	Hdac3^tm1.1Laz/Hdac3^tm1.1Laz Tg(Adipoq-cre)1Evdr/0	involves: C57BL/6 * FVB	MGI:5515398

Genotype
MGI:4889070

cn1

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz
• Genetic Background: C57BL/6-Hdac3^tm1.1Laz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced long-term object recognition memory ( J:168224 )

• 2 weeks after bilateral intrahippocampal infusion of adenoviral cre mice display enhanced long term memory for object location, forming memories following a 3 min training period that persist for up to 7 days

• however, no difference is detected in novel object recognition

• treatment with an siRNA for Nr4a2 blocks enhanced memory formation in adenoviral cre treated mice

Genotype
MGI:5575517

cn2

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz
• Genetic Background: involves: C57BL/6

liver/biliary system

hepatic steatosis ( J:206152 )

• hepatosteatosis without obvious inflammation in mice injected with adenovirus expressing cre in the liver

Genotype
MGI:5515397

cn3

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

mortality/aging

premature death ( J:199860 )

• no viable adults are obtained; mice are born at the expected Mendelian ratio, but none survive beyond 25 days of age

postnatal lethality, incomplete penetrance ( J:199860 )

• more than 50% die before postnatal day 5 (P5); remaining animals display failure to thrive and a wasting phenotype

growth/size/body

cachexia ( J:199860 )

• animals surviving past P5 fail to thrive and display a wasting phenotype

Genotype
MGI:5515396

cn4

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz; Tg(Retn-cre)1Laz/0
• Genetic Background: involves: C57BL/6

normal phenotype

no abnormal phenotype detected ( J:199860 )

• mice show no overt abnormalities and survive until adulthood

Genotype
MGI:5515398

cn5

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz; Tg(Adipoq-cre)1Evdr/0
• Genetic Background: involves: C57BL/6 * FVB

mortality/aging

mortality/aging ( J:199860 )

N • mice show no reduction in survival to at least 6 months