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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Akt2tm1.2Mbb
targeted mutation 1.2, Morris J Birnbaum
MGI:4889113
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Akt2tm1.2Mbb/Akt2tm1.2Mbb
Tg(Alb1-cre)1Khk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL MGI:4889114
cn2
Akt2tm1.2Mbb/Akt2tm1.2Mbb
Lepob/Lepob
Tg(Alb1-cre)1Khk/0
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL MGI:4889115


Genotype
MGI:4889114
cn1
Allelic
Composition
Akt2tm1.2Mbb/Akt2tm1.2Mbb
Tg(Alb1-cre)1Khk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1.2Mbb mutation (1 available); any Akt2 mutation (53 available)
Tg(Alb1-cre)1Khk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• in fed mice fed a Surwit high-fat diet at 1 and 4 months

growth/size/body
N
• mice exhibit normal body weight and susceptibility to diet-induced obesity

liver/biliary system
• in fed mice fed a Surwit high-fat diet at 1 and 4 months




Genotype
MGI:4889115
cn2
Allelic
Composition
Akt2tm1.2Mbb/Akt2tm1.2Mbb
Lepob/Lepob
Tg(Alb1-cre)1Khk/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2tm1.2Mbb mutation (1 available); any Akt2 mutation (53 available)
Lepob mutation (5 available); any Lep mutation (21 available)
Tg(Alb1-cre)1Khk mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• fasted mice exhibit increased plasma glucose levels compared with Akt2tm1Mbb Lepob homozygotes
• mice exhibit reduced lipogenesis compared to in Akt2tm1Mbb Lepob homozygotes
• mice exhibit decreased liver triglyceride levels compared with Akt2tm1Mbb Lepob homozygotes

growth/size/body
• mice exhibit decreased body weight compared with Akt2tm1Mbb Lepob homozygotes
• however, body composition was normal

liver/biliary system
• mice exhibit decreased liver triglyceride levels compared with Akt2tm1Mbb Lepob homozygotes
• mice exhibit decreased liver weight compared with Akt2tm1Mbb Lepob homozygotes





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory