Analysis Tools
reproductive system
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• the number of primary follicles is increased (double at day 8.5 and 1.5-fold at 42 days) compared to in wild-type mice
• however, the number of primary follicles is normal at 100 days and later
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• only at day 8.5, mice exhibit increased secondary follicles compared with wild-type mice
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• at 100 and 250 days, mice exhibit fewer antral follicles compared with wild-type mice
• however, follicle numbers are normal by 400 days
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• more atretic secondary follicles are observed at 42 and 250 days
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• mice exhibit a more rapid depletion of primordial follicle pool compared with wild-type mice
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• 3 of 7 female mice cease reproducing at day 210 compared with wild-type mice that continue to reproduce until at least 270 days
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mortality/aging
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• 3 of 7 female mice cease reproducing at day 210 compared with wild-type mice that continue to reproduce until at least 270 days
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endocrine/exocrine glands
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• the number of primary follicles is increased (double at day 8.5 and 1.5-fold at 42 days) compared to in wild-type mice
• however, the number of primary follicles is normal at 100 days and later
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• only at day 8.5, mice exhibit increased secondary follicles compared with wild-type mice
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• at 100 and 250 days, mice exhibit fewer antral follicles compared with wild-type mice
• however, follicle numbers are normal by 400 days
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• more atretic secondary follicles are observed at 42 and 250 days
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• mice exhibit a more rapid depletion of primordial follicle pool compared with wild-type mice
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