Phenotypes associated with this allele

• Allele Symbol: Alox15^tm1.1Nadl
• Allele Name: targeted mutation 1.1, Jerry Nadler
• Allele ID: MGI:4889210
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Alox15^tm1.1Nadl/Alox15^tm1.1Nadl Tg(Pdx1-cre)89.1Dam/0	involves: C57BL/6 * CBA	MGI:5689832

Genotype
MGI:5689832

cn1

• Allelic Composition: Alox15^tm1.1Nadl/Alox15^tm1.1Nadl; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell mass ( J:224344 )

• mice fed a high-fat diet for 20 weeks exhibit enhanced beta-cell mass

pancreatic islet hyperplasia ( J:224344 )

• in mice fed a high-fat diet for 20 weeks

abnormal pancreas physiology ( J:224344 )

• islets in vitro show lower insulin secretion at low glucose and greater insulin secretion at high glucose after 24 hours of cytokine treatment compared to wild-type islets, indicating that islets exhibit resistance to cytokine toxicity in vitro

abnormal pancreatic beta cell physiology ( J:224344 )

• mice fed a high-fat diet for 20 weeks exhibit reduced beta cell death compared to controls

increased insulin secretion ( J:224344 )

• mice fed a high-fat diet for 20 weeks exhibit improved insulin secretion after glucose injections

homeostasis/metabolism

increased insulin secretion ( J:224344 )

• mice fed a high-fat diet for 20 weeks exhibit improved insulin secretion after glucose injections

abnormal enzyme/coenzyme level ( J:224344 )

• mice fed a high-fat diet for 20 weeks show increased islet antioxidant enzyme levels

improved glucose tolerance ( J:224344 )

• STZ-treated mice show improved glucose tolerance

• mice fed a high-fat diet for 20 weeks are protected from glycemic deterioration, showing glucose tolerance similar to mice fed a normal chow diet and higher insulin levels after glucose injections

decreased susceptibility to non-insulin-dependent diabetes ( J:224344 )

♂ • males injected with low-dose streptozotocin (STZ) show an initial hyperglycemia by day 10 of STZ treatment as seen in controls but thereafter blood glucose remain stable and do not worsen as in controls, indicating protection from STZ-induced glycemic deterioration

cellular

abnormal redox activity ( J:224344 )

• islets in vitro show almost completely blocked ROS production after 24 hours of cytokine treatment and marker analysis of islets shows that they are protected from chronic cytokine-induced oxidative and ER stress

• mice fed a high-fat diet for 20 weeks show decreased islet oxidative stress and increased antioxidant enzyme levels

growth/size/body

growth/size/body region phenotype ( J:224344 )

N • mice fed a high-fat diet for 20 weeks exhibit similar weight and percent fat mass as controls and show no differences in adipocyte size or macrophage infiltration into adipocytes