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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(CAG-Rpgr)mRDefWrght
transgene insertion mRDef, Rachel Wright
MGI:4936750
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Tg(CAG-Rpgr)mRDefWrght/0
Rpgrtm1Tili/Rpgrtm1Tili 		involves: 129S4/SvJae * C57BL/6J MGI:5313499
cx2
 		Tg(CAG-Rpgr)mROrfWrght/0
Tg(CAG-Rpgr)mRDefWrght/0
Rpgrtm1Tili/Rpgrtm1Tili 		involves: 129S4/SvJae * C57BL/6J MGI:5313506
tg3
 		Tg(CAG-Rpgr)mRDefWrght/0 C57BL/6-Tg(CAG-Rpgr)mRDefWrght MGI:5313503


Genotype
MGI:5313499
cx1
Allelic
Composition		 Tg(CAG-Rpgr)mRDefWrght/0
Rpgrtm1Tili/Rpgrtm1Tili
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Tili mutation (0 available); any Rpgr mutation (10 available)
Tg(CAG-Rpgr)mRDefWrght mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
short photoreceptor inner segment ( J:181417 )
• by 2 months of age, the inner segments of the retina are shortened
short photoreceptor outer segment ( J:181417 )
• by 2 months of age, the outer segments of the retina are shortened
disorganized photoreceptor outer segment ( J:181417 )
• outer segments are disorganized with disruption of the conventional parallel arrangement of disc membranes and poorly defined outer segment morphologies; perimeters are undefined and disc diameters are greatly expanded
• stacks of disc membranes are occasionally arranged parallel to the long axis of the outer segments instead of the normal perpendicular orientation
abnormal retina cone cell morphology ( J:181417 )
• cone opsins show mislocalization in the inner segment, perinuclear regions and synaptic terminals
retina photoreceptor degeneration ( J:181417 )
• photoreceptor cell loss is seen by 2 months of age
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age
abnormal retina outer nuclear layer morphology ( J:181417 )
• by 2 months of age, mutants show a decrease in the number of nuclei in the outer nuclear layer

nervous system
short photoreceptor inner segment ( J:181417 )
• by 2 months of age, the inner segments of the retina are shortened
short photoreceptor outer segment ( J:181417 )
• by 2 months of age, the outer segments of the retina are shortened
disorganized photoreceptor outer segment ( J:181417 )
• outer segments are disorganized with disruption of the conventional parallel arrangement of disc membranes and poorly defined outer segment morphologies; perimeters are undefined and disc diameters are greatly expanded
• stacks of disc membranes are occasionally arranged parallel to the long axis of the outer segments instead of the normal perpendicular orientation
abnormal retina cone cell morphology ( J:181417 )
• cone opsins show mislocalization in the inner segment, perinuclear regions and synaptic terminals
retina photoreceptor degeneration ( J:181417 )
• photoreceptor cell loss is seen by 2 months of age
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 3 DOID:0110414 OMIM:300029
 J:181417




Genotype
MGI:5313506
cx2
Allelic
Composition		 Tg(CAG-Rpgr)mROrfWrght/0
Tg(CAG-Rpgr)mRDefWrght/0
Rpgrtm1Tili/Rpgrtm1Tili
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rpgrtm1Tili mutation (0 available); any Rpgr mutation (10 available)
Tg(CAG-Rpgr)mRDefWrght mutation (0 available)
Tg(CAG-Rpgr)mROrfWrght mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina photoreceptor degeneration ( J:181417 )
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age

nervous system
retina photoreceptor degeneration ( J:181417 )
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age




Genotype
MGI:5313503
tg3
Allelic
Composition		 Tg(CAG-Rpgr)mRDefWrght/0
Genetic
Background		 C57BL/6-Tg(CAG-Rpgr)mRDefWrght
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina photoreceptor degeneration ( J:181417 )
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age

nervous system
retina photoreceptor degeneration ( J:181417 )
• retinal cell degeneration is rapid with complete loss of photoreceptors by 8 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 3 DOID:0110414 OMIM:300029
 J:181417




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory