Phenotypes associated with this allele

• Allele Symbol: Kif16b^tm1.2Noh
• Allele Name: targeted mutation 1.2, Nobutaka Hirokawa
• Allele ID: MGI:4936840
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif16b^tm1.2Noh/Kif16b^tm1.2Noh	chimera involves: 129S6/SvEvTac	MGI:4936841

Genotype
MGI:4936841

hm1

• Allelic Composition: Kif16b^tm1.2Noh/Kif16b^tm1.2Noh
• Genetic Background: chimera involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:168572 )

• embryos derived from tetraploid rescue exhibit lethal arrest at the blastocyst stage

embryo

abnormal embryo development ( J:168572 )

• embryos derived from tetraploid rescue exhibit indistinguishable primitive endoderm and epiblast that appear as cell clumps resembling the inner cell mass of the blastocyst unlike in wild-type mice

• embryos derived from tetraploid rescue exhibit impaired basement membrane development compared with wild-type mice

embryonic growth arrest ( J:168572 )

• embryos derived from tetraploid rescue exhibit lethal arrest at the blastocyst stage

absent embryonic epiblast ( J:168572 )

• embryos derived from tetraploid rescue fail to develop an epiblast epithelium unlike wild-type mice

abnormal primitive endoderm morphology ( J:168572 )

• embryos derived from tetraploid rescue exhibit impaired primitive endoderm development compared with wild-type mice