Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-XBP1*/Venus)#Miur
• Allele Name: transgene insertion, Masayuki Miura
• Allele ID: MGI:4939273
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnajb9^Gt(KST256)Byg/Dnajb9^Gt(KST256)Byg Tg(CAG-XBP1*/Venus)#Miur/?	involves: 129P2/OlaHsd * C57BL/6	MGI:5699101

Genotype
MGI:5699101

cx1

• Allelic Composition: Dnajb9^{Gt(KST256)Byg}/Dnajb9^{Gt(KST256)Byg}; Tg(CAG-XBP1*/Venus)#Miur/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal endoplasmic reticulum morphology ( J:226674 )

• ER distention in renal tubular epithelial cells and serous cells of salivary glands

• green fluorescence due to ER stress in kidneys and lungs

• GFP immunofluorescence in beta-cells of pancreatic islets

• dilated ER in pancreatic acinar cells at 8 months

increased pancreatic beta cell apoptosis ( J:226674 )

• significant increase in the number of TUNEL+ beta cells per pancreatic islet

endocrine/exocrine glands

increased pancreatic beta cell apoptosis ( J:226674 )

• significant increase in the number of TUNEL+ beta cells per pancreatic islet

abnormal pancreatic acinar cell morphology ( J:226674 )

• vacuolated pancreatic acinar cells at 8 months but not at 8 weeks

abnormal pancreatic acinar cell zymogen granule morphology ( J:226674 )

• immature zymogen granules at 8 months of age

abnormal pancreatic alpha cell morphology ( J:226674 )

• vacuolated alpha-cells

abnormal pancreatic beta cell morphology ( J:226674 )

• vacuolated beta-cells

decreased pancreatic beta cell number ( J:226674 )

• 21% decrease in beta-cell numbers in islets where increased apoptosis is occurring

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:226674 )

• vacuolated pancreatic acinar cells at 8 months but not at 8 weeks

abnormal pancreatic acinar cell zymogen granule morphology ( J:226674 )

• immature zymogen granules at 8 months of age