Phenotypes associated with this allele

• Allele Symbol: Rheb^tm1.1Pfw
• Allele Name: targeted mutation 1.1 Paul Worley
• Allele ID: MGI:4939473
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rheb^tm1.1Pfw/Rheb^tm1.1Pfw	involves: C57BL/6	MGI:4939477
cx2	Rheb^tm1.1Pfw/Rheb^tm1.1Pfw Rhebl1^tm1.1Pfw/Rhebl1^tm1.1Pfw	involves: C57BL/6	MGI:4939478
cx3	Rheb^tm1.1Pfw/Rheb^+ Rhebl1^tm1.1Pfw/Rhebl1^tm1.1Pfw	involves: C57BL/6	MGI:4939479

Genotype
MGI:4939477

hm1

• Allelic Composition: Rheb^tm1.1Pfw/Rheb^tm1.1Pfw
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:168571 )

• die between E10.5 and E11.5

Genotype
MGI:4939478

cx2

• Allelic Composition: Rheb^tm1.1Pfw/Rheb^tm1.1Pfw; Rhebl1^tm1.1Pfw/Rhebl1^tm1.1Pfw
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:168571 )

• similar to mice homozygous for the Rheb allele alone

Genotype
MGI:4939479

cx3

• Allelic Composition: Rheb^tm1.1Pfw/Rheb⁺; Rhebl1^tm1.1Pfw/Rhebl1^tm1.1Pfw
• Genetic Background: involves: C57BL/6

mortality/aging

mortality/aging ( J:168571 )

N • unlike double homozygous mice, mice with one wild-type allele of Rheb are viable