Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}
• Allele Name: targeted mutation 1, Paul Worley
• Allele ID: MGI:4939476
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sor^+ Rheb^tm1Pfw/Rheb^tm1Pfw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4939481
cn2	Gt(ROSA)26Sor^tm1(CAG-Rheb*)Pfw/Gt(ROSA)26Sor^tm1(CAG-Rheb*)Pfw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4939482

Genotype
MGI:4939481

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}/Gt(ROSA)26Sor⁺; Rheb^tm1Pfw/Rheb^tm1Pfw; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:168571 )

N • brain size, myelination, and oligodendrocyte numbers are similar to controls unlike in mutant mice without the knock-in allele in Gt(ROSA)26Sor

Genotype
MGI:4939482

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}/Gt(ROSA)26Sor^{tm1(CAG-Rheb*)Pfw}; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

nervous system

increased brain size ( J:168571 )

increased brain weight ( J:168571 )

abnormal cerebral cortex morphology ( J:168571 )

• increase in the size of the soma of cortical neurons

thickened cerebral cortex ( J:168571 )

increased oligodendrocyte number ( J:168571 )

• increase in the number of mature oligodendrocytes at P7 but not at P14

neuron hypertrophy ( J:168571 )

• increase in the size of the soma of cortical neurons

hypermyelination ( J:168571 )

• during early postnatal stages but not at 4-6 weeks or 3 months of age