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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Enpp1m1Amgn
mutation 1, Amgen
MGI:4939484
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Enpp1m1Amgn/Enpp1m1Amgn involves: C3H/HeSnJ * C57BL/6J * Swiss MGI:4939489


Genotype
MGI:4939489
hm1
Allelic
Composition		 Enpp1m1Amgn/Enpp1m1Amgn
Genetic
Background		 involves: C3H/HeSnJ * C57BL/6J * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Enpp1m1Amgn mutation (0 available); any Enpp1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal knee joint morphology ( J:168664 )
• mice exhibit calcification of the articular cartilage in the knee joint unlike in wild-type mice

skeleton
calcified tendon ( J:168664 )
• in the Achilles and patella tendons
exostosis ( J:168664 )
• hyperostosis of the vertebrae including ribs and intervertebral disc spaces
• in metatarsal, metacarpal, and interphalangeal joints
abnormal joint morphology ( J:168664 )
• mice develop severe crystal-related arthropathy unlike wild-type mice
abnormal knee joint morphology ( J:168664 )
• mice exhibit calcification of the articular cartilage in the knee joint unlike in wild-type mice
calcified joint ( J:168664 )
• mice exhibit calcification of the articular cartilage in the knee joint unlike in wild-type mice
decreased joint mobility ( J:168664 )
• mice exhibit stiff joints

cardiovascular system
calcified artery ( J:168664 )
• in vasculature associated with the aorta, heart, and kidneys

nervous system
abnormal spinal cord morphology ( J:168664 )
• mice exhibit compression of the spinal cord and ganglion roots without destruction of the nucleus pulposus compared with wild-type mice

behavior/neurological

muscle
calcified tendon ( J:168664 )
• in the Achilles and patella tendons




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory