Phenotypes associated with this allele

• Allele Symbol: Mesd^tm1Bch
• Allele Name: targeted mutation 1, Bernadette C Holdener
• Allele ID: MGI:4939501
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesd^tm1Bch/Mesd^tm1Bch	B6.129-Mesd^tm1Bch	MGI:4939583
ht2	Mesd^tm1Bch/Mesd^tm2.1Bch	involves: 129 * C57BL/6 * C57BL/6J	MGI:5568742

Genotype
MGI:4939583

hm1

• Allelic Composition: Mesd^tm1Bch/Mesd^tm1Bch
• Genetic Background: B6.129-Mesd^tm1Bch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

small embryonic epiblast ( J:168622 )

• small at E7.5

absent mesoderm ( J:168622 )

• embryos lack mesodermal derivatives

failure of primitive streak formation ( J:168622 )

abnormal parietal endoderm morphology ( J:168622 )

• embryos exhibit an expansion of parietal endoderm surrounding an underdeveloped egg cylinder unlike in wild-type mice

abnormal visceral endoderm morphology ( J:168622 )

• at E7.5, visceral endoderm contain smaller lysosome compared to in wild-type mice

Genotype
MGI:5568742

ht2

• Allelic Composition: Mesd^tm1Bch/Mesd^tm2.1Bch
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

The Mesd^tm2.1Bch allele does not complement the Mesd^tm1Bch and Tyr^c-3YPSd alleles

embryo

failure to gastrulate ( J:209024 )

small embryonic epiblast ( J:209024 )

• at E7.5 and E8.5

absent mesoderm ( J:209024 )

• mesoderm fails to differentiate