All Phenotypes Irf8<tm1.1Hm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf8^tm1.1Hm
targeted mutation 1.1, Herbert Morse III
MGI:4939593

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Irf8^tm1.1Hm/Irf8^tm1.1Hm	involves: 129P2/OlaHsd * C57BL/6	MGI:4939594

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Irf8^tm1.1Hm/Irf8^tm1.1Hm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Irf8^tm1.1Hm mutation (1 available); any Irf8 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:168923 )

N	• spleen and lymph node sizes are normal • mice exhibit normal T-dependent and T-independent antibody responses

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice

hematopoietic system

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24