All Phenotypes Irf8<tm1.1Hm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Irf8^tm1.1Hm
targeted mutation 1.1, Herbert Morse III
MGI:4939593

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19⁺ Irf8^tm1.1Hm/Irf8^tm1.1Hm	involves: 129P2/OlaHsd * C57BL/6	MGI:4939594

Allelic Composition	Cd19^tm1(cre)Cgn/Cd19⁺ Irf8^tm1.1Hm/Irf8^tm1.1Hm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (58 available)
Irf8^tm1.1Hm mutation (1 available); any Irf8 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:168923 )

N	• spleen and lymph node sizes are normal • mice exhibit normal T-dependent and T-independent antibody responses

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice

hematopoietic system

decreased follicular B cell number ( J:168923 )

• the proportion of AA4-B220+IgM^low CD19+ follicular B cells is decreased compared to in control mice

increased B cell number ( J:168923 )

• the frequency of CD19+B220+ B cells is increased compared to in control mice

• the number of total peritoneal B cells is increased compared to in control mice

increased transitional stage B cell number ( J:168923 )

• the frequency of B220+AA4+ transitional B cells is increased compared to in control mice

• the absolute number of transitional B cells is increased compared to in control mice

increased B-2 B cell number ( J:168923 )

• in the peritoneum

increased follicular B cell number ( J:168923 )

• the absolute number of follicular B cells is increased compared to in control mice

abnormal spleen marginal zone morphology ( J:168923 )

• mice exhibit enlarged marginal zones surrounding white pulp follicles compared with control mice

increased marginal zone B cell number ( J:168923 )

• the frequency of AA4-B220+IgM^hi CD19+ marginal zone B cells is increased compared to in control mice

• the absolute number of marginal zone B cells is increased compared to in control mice

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