Phenotypes associated with this allele

• Allele Symbol: Kifbp^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4939684
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kifbp^tm1a(KOMP)Wtsi/Kifbp^tm1a(KOMP)Wtsi	C57BL/6N-Kifbp^tm1a(KOMP)Wtsi/Wtsi	MGI:5639391
ht2	Kifbp^tm1a(KOMP)Wtsi/Kifbp^+	C57BL/6N-Kifbp^tm1a(KOMP)Wtsi/Wtsi	MGI:6771995

Genotype
MGI:5639391

hm1

• Allelic Composition: Kifbp^{tm1a(KOMP)Wtsi}/Kifbp^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Kifbp^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0728_3_H07

Data Sources

IMPC Data for Kifbp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

absent extracranial vertebral artery segment ( J:239583 )

DMDD

absent posterior communicating artery ( J:239583 )

DMDD

dilated liver sinusoidal space ( J:239583 )

DMDD

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal ductus venosus morphology ( J:239583 )

DMDD

abnormal ductus venosus topology ( J:239583 )

DMDD

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

craniofacial

cleft palate ( J:239583 )

DMDD

digestive/alimentary system

cleft palate ( J:239583 )

DMDD

embryo

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal placenta morphology ( J:261316 )

• fibrotic/necrotic areas in the placenta at E14.5

• distorted spongiotrophoblast/labyrinth ratio at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

placenta necrosis ( J:261316 )

• necrotic areas in the placenta at E14.5

endocrine/exocrine glands

abnormal adenohypophysis morphology ( J:239583 )

DMDD

growth/size/body

cleft palate ( J:239583 )

DMDD

epididymal cyst ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

immune system

blood in lymph vessels ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

liver/biliary system

dilated liver sinusoidal space ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 , J:261316 )

IMPC - WTSI (J:211773)

MGI

• lethality at P14, with viable fetuses at E14.5 (J:261316)

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

neoplasm

increased trigeminal neuroma incidence ( J:239583 )

DMDD

embryo tumor ( J:239583 )

DMDD

nervous system

absent posterior communicating artery ( J:239583 )

DMDD

abnormal adenohypophysis morphology ( J:239583 )

DMDD

increased trigeminal neuroma incidence ( J:239583 )

DMDD

small superior cervical ganglion ( J:239583 )

DMDD

small trigeminal ganglion ( J:239583 )

DMDD

absent hypoglossal nerve ( J:239583 )

DMDD

thin hypoglossal nerve ( J:239583 )

DMDD

thin vagus nerve ( J:239583 )

DMDD

reproductive system

epididymal cyst ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

Genotype
MGI:6771995

ht2

• Allelic Composition: Kifbp^{tm1a(KOMP)Wtsi}/Kifbp⁺
• Genetic Background: C57BL/6N-Kifbp^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0728_3_H07

Data Sources

IMPC Data for Kifbp

homeostasis/metabolism

increased circulating chloride level ( J:211773 )

♂

IMPC - WTSI