Phenotypes associated with this allele

• Allele Symbol: Tigit^tm1Sdl
• Allele Name: targeted mutation 1, Steven D Levin
• Allele ID: MGI:4939784
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tigit^tm1Sdl/Tigit^tm1Sdl	involves: C57BL/6	MGI:4939786
cx2	Tigit^tm1Sdl/Tigit^tm1Sdl Tg(Tcra2D2,Tcrb2D2)1Kuch/0	involves: C57BL/6	MGI:4939787

Genotype
MGI:4939786

hm1

• Allelic Composition: Tigit^tm1Sdl/Tigit^tm1Sdl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased T cell proliferation ( J:168902 )

• upon restimulation with antigenic peptide

immune system

immune system phenotype ( J:209990 )

N • normal levels of serum Ifng and NK cell intracellular Ifng after LPS-induced endotoxicosis

increased T cell proliferation ( J:168902 )

• upon restimulation with antigenic peptide

abnormal professional antigen presenting cell physiology ( J:168902 )

• antibody presenting cells exhibit enhanced proliferation promotion compared with wild-type cells

decreased interleukin-10 secretion ( J:168902 )

• in unstimulated and stimulated T cells

increased susceptibility to experimental autoimmune encephalomyelitis ( J:168902 )

• following MOG35-55 treatment, mice exhibit full-blown disease unlike wild-type mice

hematopoietic system

increased T cell proliferation ( J:168902 )

• upon restimulation with antigenic peptide

mortality/aging

mortality/aging ( J:209990 )

N • normal survival after LPS-induced endotoxicosis

neoplasm

neoplasm ( J:209990 )

N • normal susceptibility to lung metastases after injection of B16F10 melanoma cells into tail vein

Genotype
MGI:4939787

cx2

• Allelic Composition: Tigit^tm1Sdl/Tigit^tm1Sdl; Tg(Tcra2D2,Tcrb2D2)1Kuch/0
• Genetic Background: involves: C57BL/6

immune system

decreased interleukin-10 secretion ( J:168902 )

increased susceptibility to experimental autoimmune encephalomyelitis ( J:168902 )

• unlike Tg(Tcra2D2,Tcrb2D2)1Kuch mice