All Phenotypes Tirap<tm1.1Pjh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tirap^tm1.1Pjh
targeted mutation 1.1, Paul J Hertzog
MGI:4939795

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Il6st^tm1Ern/Il6st^tm1Ern Tirap^tm1.1Pjh/Tirap^tm1.1Pjh	involves: 129S1/Sv	MGI:4939800

Allelic Composition	Il6st^tm1Ern/Il6st^tm1Ern Tirap^tm1.1Pjh/Tirap^tm1.1Pjh
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6st^tm1Ern mutation (13 available); any Il6st mutation (80 available)
Tirap^tm1.1Pjh mutation (0 available); any Tirap mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

decreased susceptibility to endotoxin shock ( J:168781 )

• LPS-treated mice exhibit increased survival and decreased serum IL6 compared with similarly treated Il6st^tm1Ern homozygotes

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:168781 )

• in LPS-treated mice compared with similarly treated Il6st^tm1Ern homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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