Phenotypes associated with this allele

• Allele Symbol: Ren1^tm1.2Sig
• Allele Name: targeted mutation 1.2, Curt Sigmund
• Allele ID: MGI:4939806
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ren1^tm1.2Sig/Ren1^tm1.2Sig	involves: C57BL/6J	MGI:4939885

Genotype
MGI:4939885

hm1

• Allelic Composition: Ren1^tm1.2Sig/Ren1^tm1.2Sig
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:169129 )

• nearly all mice die between birth and weaning

renal/urinary system

decreased urine osmolality ( J:169129 )

kidney atrophy ( J:169129 )

• severe in surviving adults

polyuria ( J:169129 )

homeostasis/metabolism

increased circulating aldosterone level ( J:169129 )

• likely compensatory

decreased urine osmolality ( J:169129 )

decreased physiological sensitivity to xenobiotic ( J:169129 )

• in response to 5-hydroxytryptamine, mice exhibit impaired vasoconstriction compared with wild-type mice

• however, mice exhibit normal contractile response to treatment with prostaglandin F2alpha, phenylephrine, and KCl

cardiovascular system

decreased mean systemic arterial blood pressure ( J:169129 )

decreased vasoconstriction ( J:169129 )

• in response to 5-hydroxytryptamine

• however, mice exhibit normal contractile response to treatment with prostaglandin F2alpha, phenylephrine, and KCl

hematopoietic system

decreased hematocrit ( J:169129 )

muscle

decreased vasoconstriction ( J:169129 )

• in response to 5-hydroxytryptamine

• however, mice exhibit normal contractile response to treatment with prostaglandin F2alpha, phenylephrine, and KCl

nervous system

abnormal baroreceptor physiology ( J:169129 )

• mice exhibit a decrease in the number of baroreflex sequences compared with wild-type mice