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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Abl1tm1.1Gcos
targeted mutation 1.1, Giulio Cossu
MGI:4939889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Abl1tm1.1Gcos/Abl1tm1.1Gcos involves: 129S1/Sv * 129X1/SvJ MGI:4939892
ht2
 		Abl1tm1.1Gcos/Abl1+ involves: 129S1/Sv * 129X1/SvJ MGI:4939893


Genotype
MGI:4939892
hm1
Allelic
Composition		 Abl1tm1.1Gcos/Abl1tm1.1Gcos
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1.1Gcos mutation (0 available); any Abl1 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myogenesis ( J:168843 )
• MyoD-activated myogenesis in fibroblasts is not suppressed by genotoxins unlike in similarly treated wild-type cells

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:168843 )
• MyoD-activated myogenesis in fibroblasts is not suppressed by genotoxins unlike in similarly treated wild-type cells




Genotype
MGI:4939893
ht2
Allelic
Composition		 Abl1tm1.1Gcos/Abl1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Abl1tm1.1Gcos mutation (0 available); any Abl1 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal myogenesis ( J:168843 )
• MyoD-activated myogenesis in fibroblasts is not suppressed by genotoxins unlike in similarly treated wild-type cells

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:168843 )
• MyoD-activated myogenesis in fibroblasts is not suppressed by genotoxins unlike in similarly treated wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory