About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rims2tm1.1Sud
targeted mutation 1.1, Thomas C Sudhof
MGI:4939895
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4939900
cx2
 		Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4939901


Genotype
MGI:4939900
cn1
Allelic
Composition		 Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rims1tm3Sud mutation (1 available); any Rims1 mutation (88 available)
Rims2tm1.1Sud mutation (1 available); any Rims2 mutation (250 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:168840 )
N
• neurons transfected with a cre-expressing lentivirus exhibit normal morphology with normal synapse size and density
abnormal synaptic vesicle number ( J:168840 )
• neurons transfected with a cre-expressing lentivirus exhibit a 2-fold decrease in the number of docked synaptic vesicles per active zone compared with untransfected cells
abnormal neuron physiology ( J:168840 )
• neurons transfected with a cre-expressing lentivirus exhibit decreased, decelerated, and desynchronized neurotransmitter release; altered calcium dependent release; and impaired presynaptic calcium influx compared with untransfected cells




Genotype
MGI:4939901
cx2
Allelic
Composition		 Rims1tm3Sud/Rims1tm3Sud
Rims2tm1.1Sud/Rims2tm1.1Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rims1tm3Sud mutation (1 available); any Rims1 mutation (88 available)
Rims2tm1.1Sud mutation (1 available); any Rims2 mutation (250 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:168840 )
• mice are viable and fertile and exhibit no obvious phenotype




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory