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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kittm1Rosay
targeted mutation 1, Kenton M Sanders and Seungil Ro
MGI:4939904
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kittm1Rosay/Kittm1Rosay involves: 129S7/SvEvBrd * C57BL/6J MGI:4940017
ht2
 		Kittm1Rosay/Kit+ involves: 129S7/SvEvBrd * C57BL/6J MGI:4940018
cx3
 		Kittm1Rosay/Kit+
Lepob/Lepob 		involves: 129S7/SvEvBrd * C57BL/6J MGI:4940020


Genotype
MGI:4940017
hm1
Allelic
Composition		 Kittm1Rosay/Kittm1Rosay
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Rosay mutation (1 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:168676 )
• mice do not survive to birth




Genotype
MGI:4940018
ht2
Allelic
Composition		 Kittm1Rosay/Kit+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Rosay mutation (1 available); any Kit mutation (182 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
white spotting ( J:168676 )
• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice

pigmentation
white spotting ( J:168676 )
• mice exhibit white patches at the end of the tail and on the belly and white paws compared with wild-type mice




Genotype
MGI:4940020
cx3
Allelic
Composition		 Kittm1Rosay/Kit+
Lepob/Lepob
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Rosay mutation (1 available); any Kit mutation (182 available)
Lepob mutation (5 available); any Lep mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal interstitial cell of Cajal morphology ( J:168676 )
• interstitial cells of Cajal networks are disrupted during the development of diabetes unlike in Kittm1Rosan heterozygotes
• mice exhibit loss of interstitial cells of Cajal unlike Kittm1Rosan heterozygotes

growth/size/body
obese ( J:168676 )
• by 4 to 6 weeks of age

homeostasis/metabolism
hyperglycemia ( J:168676 )
• by 10 to 12 weeks of age

integument
white spotting ( J:168676 )
• mice exhibit white paws and tail unlike wild-type mice

pigmentation
white spotting ( J:168676 )
• mice exhibit white paws and tail unlike wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory