Phenotypes associated with this allele

• Allele Symbol: Insm1^tm1.1Jga
• Allele Name: targeted mutation 1.1, Jaime Garcia-Anoveros
• Allele ID: MGI:4940047
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Insm1^tm1.1Jga/Insm1^tm1.1Jga	either: B6.129P2-Insm1^tm1.1Jga or (involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N)	MGI:4940050

Genotype
MGI:4940050

hm1

• Allelic Composition: Insm1^tm1.1Jga/Insm1^tm1.1Jga
• Genetic Background: either: B6.129P2-Insm1^tm1.1Jga or (involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:168833 )

• some mice die between E12.5 and E15.5

• many mice are dead by E16.5 and non-survive beyond E18.5

• however, L-DOPA treatment beginning at E7.5 improves survival of some mice to E20.5

embryonic lethality during organogenesis, incomplete penetrance ( J:168833 )

• some mice die between E12.5 and E15.5

nervous system

increased neuron apoptosis ( J:168833 )

• minimally at late embryonic stages

abnormal neuron differentiation ( J:168833 )

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length

decreased neuron number ( J:168833 )

• mice exhibit fewer nascent and mature neurons in the embryonic olfactory epithelium compared with wild-type mice

taste/olfaction

abnormal olfactory epithelium morphology ( J:168833 )

• at E14.5 and E18.5, the apical layer of proliferative progenitors is thicker than in wild-type mice

• the neuro-basal layer is thinner than in wild-type mice

• at E18.5, the number of apical cells is increased while the number of neuro-basal cells is decreased compared to in wild-type mice

• mice exhibit fewer nascent and mature neurons in the embryonic olfactory epithelium compared with wild-type mice

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length

craniofacial

abnormal olfactory epithelium morphology ( J:168833 )

• at E14.5 and E18.5, the apical layer of proliferative progenitors is thicker than in wild-type mice

• the neuro-basal layer is thinner than in wild-type mice

• at E18.5, the number of apical cells is increased while the number of neuro-basal cells is decreased compared to in wild-type mice

• mice exhibit fewer nascent and mature neurons in the embryonic olfactory epithelium compared with wild-type mice

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length

respiratory system

abnormal olfactory epithelium morphology ( J:168833 )

• at E14.5 and E18.5, the apical layer of proliferative progenitors is thicker than in wild-type mice

• the neuro-basal layer is thinner than in wild-type mice

• at E18.5, the number of apical cells is increased while the number of neuro-basal cells is decreased compared to in wild-type mice

• mice exhibit fewer nascent and mature neurons in the embryonic olfactory epithelium compared with wild-type mice

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length

cellular

increased neuron apoptosis ( J:168833 )

• minimally at late embryonic stages

abnormal neuron differentiation ( J:168833 )

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length

growth/size/body

abnormal olfactory epithelium morphology ( J:168833 )

• at E14.5 and E18.5, the apical layer of proliferative progenitors is thicker than in wild-type mice

• the neuro-basal layer is thinner than in wild-type mice

• at E18.5, the number of apical cells is increased while the number of neuro-basal cells is decreased compared to in wild-type mice

• mice exhibit fewer nascent and mature neurons in the embryonic olfactory epithelium compared with wild-type mice

• the embryonic olfactory epithelium exhibits an increase in apical progenitors and a decrease in basal progenitors compared with wild-type mice

• the embryonic olfactory epithelium exhibits fewer terminally dividing neuronogenic progenitors compared to in wild-type mice

• however, olfactory epithelium progenitors exhibit normal numbers of cycling cells, S-phase, and cell cycle length