Analysis Tools
mortality/aging
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• no neonatal mice are observed
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cardiovascular system
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• at E9 to E10, ventral forebrains and ventral spinal cords are almost entirely avascular unlike in wild-type mice
• at E12.5, ventral forebrain and spinal cord vessels end in disorganized vascular structures or glomeruloid tufts unlike in wild-type mice
• abnormal vessels exhibit abnormal basement membrane deposition and smooth muscle cell association compared to in wild-type mice
• however, mice exhibit normal lung vasculature and perineural vascular plexus
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• at E9 to E10, ventral forebrain is almost entirely avascular unlike in wild-type mice
• at E12.5, ventral forebrain vessels end in disorganized vascular structures or glomeruloid tufts unlike in wild-type mice
• at E15.5, dorsal forebrain vasculature remains sparse with abnormal tufted vessels unlike in wild-type mice
• at E15.5, the hypothalamus contains enlarged vessels at reduced density compared to in wild-type mice
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• at E12.5, ventral forebrain and spinal cord vessels end in disorganized vascular structures or glomeruloid tufts unlike in wild-type mice
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hemorrhage
(
J:169064
)
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• at E12.5, mice exhibit blood accumulation in the base of the forebrain and along the length of the spinal cord unlike wild-type mice
• at E15.5, mice exhibit blood accumulation within the entire forebrain and spinal cord unlike wild-type mice
• at birth, mice exhibit blood accumulation in the forebrain and in the meninges overlying the brain unlike wild-type mice
• however, blood accumulation is not observed in any other part of the brain
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nervous system
| N |
• mice exhibit normal neural tube patterning and radial glial cell processes
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• at E9 to E10, ventral forebrain is almost entirely avascular unlike in wild-type mice
• at E12.5, ventral forebrain vessels end in disorganized vascular structures or glomeruloid tufts unlike in wild-type mice
• at E15.5, dorsal forebrain vasculature remains sparse with abnormal tufted vessels unlike in wild-type mice
• at E15.5, the hypothalamus contains enlarged vessels at reduced density compared to in wild-type mice
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• at birth, mice exhibit enlarged forebrain ventricles compared with wild-type mice
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craniofacial
cleft palate
(
J:169064
)
|
• at E15.5 and P0
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respiratory system
small lung
(
J:169064
)
|
• at E15.5
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digestive/alimentary system
cleft palate
(
J:169064
)
|
• at E15.5 and P0
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growth/size/body
cleft palate
(
J:169064
)
|
• at E15.5 and P0
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megacephaly
(
J:169064
)
|
• at birth
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