Analysis Tools|
Allele Symbol Allele Name Allele ID |
Hand2tm2.1Dsr targeted mutation 2.1, Deepak Srivastava MGI:4940061 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E12.5, mice exhibit narrowed outflow tract and hypoplastic outlet or subpulmonary conus compared with wild-type mice
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• at E14.5, the right ventricular cavity is smaller than in wild-type mice
• however, the right ventricular muscle wall thickness is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E10.5
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• shortened
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• severe
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• at E9.0, mice exhibit increased apoptosis in the pharyngeal mesoderm compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E12.5
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• slightly at E9.5
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• slightly at E9.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E13.5
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• immature truncus arteriosis
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• mice lack the anlage of the tricuspid valve between the right atrium and ventricle unlike wild-type mice
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• at E9.5 but not as severely as in Hand2tm1Dsr homozygotes
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• at E12.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at E15.5
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• shortened at E10.5 and E13.5
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• at E13.5, but not at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E9.5, mice exhibit fewer progenitor cells migration into the outflow tract compared with control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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