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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Tbx1-cre)#Dsr
transgene insertion, Deepak Srivastava
MGI:4940066
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tbx1-cre)#Dsr/0 		involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:4940095
cn2
 		Hand2tm1Dsr/Hand2tm2.1Dsr
Tg(Tbx1-cre)#Dsr/0 		involves: 129 * 129S7/SvEvBrd * C57BL/6 MGI:4940094


Genotype
MGI:4940095
cn1
Allelic
Composition		 Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tbx1-cre)#Dsr/0
Genetic
Background		 involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Tg(Tbx1-cre)#Dsr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiac outflow tract development ( J:169213 )
• at E12.5, mice exhibit narrowed outflow tract and hypoplastic outlet or subpulmonary conus compared with wild-type mice
decreased heart right ventricle size ( J:169213 )
• at E14.5, the right ventricular cavity is smaller than in wild-type mice
• however, the right ventricular muscle wall thickness is normal




Genotype
MGI:4940094
cn2
Allelic
Composition		 Hand2tm1Dsr/Hand2tm2.1Dsr
Tg(Tbx1-cre)#Dsr/0
Genetic
Background		 involves: 129 * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Tg(Tbx1-cre)#Dsr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal cardiac outflow tract development ( J:169213 )
• shortened at E10.5 and E13.5
decreased heart right ventricle size ( J:169213 )
• at E13.5, but not at E10.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory