All Phenotypes Tg(Mef2c-cre)#Blk MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Mef2c-cre)#Blk
transgene insertion, Brian L Black
MGI:4940068

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Mef2c-cre)#Blk/0	involves: 129 * 129S7/SvEvBrd * C57BL/6	MGI:4940093
cn2	Nkx2-5^tm1Krc/Nkx2-5^tm1Krc Tg(Mef2c-cre)#Blk/0	involves: 129 * C57BL/6	MGI:5643690
cn3	Arhgef25^tm1.1Xya/Arhgef25^tm1.1Xya Tg(Mef2c-cre)#Blk/0	involves: 129S4/SvJaeSor * C57BL/6	MGI:5426697
cn4	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Mef2c-cre)#Blk/0	Not Specified	MGI:5444487
cn5	Zic3^tm1.1Smwa/Y Tg(Mef2c-cre)#Blk/0	Not Specified	MGI:5476841

Allelic Composition	Hand2^tm1Dsr/Hand2^tm2.1Dsr Tg(Mef2c-cre)#Blk/0
Genetic Background	involves: 129 * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1Dsr mutation (0 available); any Hand2 mutation (12 available)
Hand2^tm2.1Dsr mutation (0 available); any Hand2 mutation (12 available)
Tg(Mef2c-cre)#Blk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169213 )

• mice die at E13.5

cardiovascular system

thin myocardium ( J:169213 )

persistent truncus arteriosus ( J:169213 )

• immature truncus arteriosis

abnormal tricuspid valve morphology ( J:169213 )

• mice lack the anlage of the tricuspid valve between the right atrium and ventricle unlike wild-type mice

ventricular septal defect ( J:169213 )

decreased heart right ventricle size ( J:169213 )

• at E9.5 but not as severely as in Hand2^tm1Dsr homozygotes

heart right ventricle hypoplasia ( J:169213 )

• at E12.5

muscle

thin myocardium ( J:169213 )

Allelic Composition	Nkx2-5^tm1Krc/Nkx2-5^tm1Krc Tg(Mef2c-cre)#Blk/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx2-5^tm1Krc mutation (0 available); any Nkx2-5 mutation (21 available)
Tg(Mef2c-cre)#Blk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:214093 )

• early embryonic lethality at E10-E10.5

cardiovascular system

abnormal cardiac outflow tract development ( J:214093 )

• foreshortened outflow tract

absent heart right ventricle ( J:214093 )

• loss of right ventricle

Allelic Composition	Arhgef25^tm1.1Xya/Arhgef25^tm1.1Xya Tg(Mef2c-cre)#Blk/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef25^tm1.1Xya mutation (0 available); any Arhgef25 mutation (37 available)
Tg(Mef2c-cre)#Blk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:183551 )

N	• mice are born in the expected Mendelian ratio

cardiovascular system

cardiovascular system phenotype ( J:183551 )

N	• mice exhibit normal development of the second heart field

Allelic Composition	Irx3^tm3Hui/Irx3^tm3Hui Irx5^tm3Hui/Irx5^tm3Hui Tg(Mef2c-cre)#Blk/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irx3^tm3Hui mutation (0 available); any Irx3 mutation (25 available)
Irx5^tm3Hui mutation (0 available); any Irx5 mutation (31 available)
Tg(Mef2c-cre)#Blk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:189007 )

• recapitulates outflow tract abnormalities seen in germ line double null mice

double outlet right ventricle ( J:189007 )

Allelic Composition	Zic3^tm1.1Smwa/Y Tg(Mef2c-cre)#Blk/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Mef2c-cre)#Blk mutation (0 available)
Zic3^tm1.1Smwa mutation (0 available); any Zic3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:194989 )

• viable with no cardiac looping defects detected

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