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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf14tm1Csj
targeted mutation 1, Choon-Soo Jeong
MGI:4940320
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf14tm1Csj/Tnfrsf14tm1Csj B6.Cg-Tnfrsf14tm1Csj MGI:4940889


Genotype
MGI:4940889
hm1
Allelic
Composition		 Tnfrsf14tm1Csj/Tnfrsf14tm1Csj
Genetic
Background		 B6.Cg-Tnfrsf14tm1Csj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf14tm1Csj mutation (0 available); any Tnfrsf14 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:169369 )
• all mice survive DSS treatment unlike similarly treated wild-type mice

immune system
decreased susceptibility to induced colitis ( J:169369 )
• DSS-treated mice exhibit reduced and delayed clinical symptoms of colitis, increased cell proliferation in the colon, delayed leukocyte infiltration into the lamina propria, and delayed cytokine expression (IL6, MCP1, IFN-gamma, TNFalpha, and IL10) compared with similarly treated wild-type mice
• all mice survive DSS treatment unlike similarly treated wild-type mice
decreased interferon-gamma secretion ( J:169369 )
• in DSS-treated mice
decreased interleukin-10 secretion ( J:169369 )
• in DSS-treated mice
decreased interleukin-6 secretion ( J:169369 )
• in DSS-treated mice

homeostasis/metabolism
decreased susceptibility to xenobiotic induced morbidity/mortality ( J:169369 )
• all mice survive DSS treatment unlike similarly treated wild-type mice

digestive/alimentary system
decreased susceptibility to induced colitis ( J:169369 )
• DSS-treated mice exhibit reduced and delayed clinical symptoms of colitis, increased cell proliferation in the colon, delayed leukocyte infiltration into the lamina propria, and delayed cytokine expression (IL6, MCP1, IFN-gamma, TNFalpha, and IL10) compared with similarly treated wild-type mice
• all mice survive DSS treatment unlike similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory