Phenotypes associated with this allele

• Allele Symbol: Ecm1^tm1Bsun
• Allele Name: targeted mutation 1, Bing Sun
• Allele ID: MGI:4940879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ecm1^tm1Bsun/Ecm1^tm1Bsun	involves: 129 * C57BL/6	MGI:4940882

Genotype
MGI:4940882

hm1

• Allelic Composition: Ecm1^tm1Bsun/Ecm1^tm1Bsun
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:168252 )

• mice develop symptoms of an auto-inflammatory disease and do not survive beyond 6 to 8 weeks of age

immune system

immune system phenotype ( J:168252 )

N • when bone marrow is used to repopulate irradiated wild-type mice, in vivo TH1 and TH17 responses are normal

decreased IgE level ( J:168252 )

• when bone marrow is used to repopulate irradiated wild-type mice, intranasal ovalbumin challenge induces reduced ovalbumin-IgE serum levels compared with similarly treated wild-type mice

abnormal T-helper 2 physiology ( J:168252 )

• when bone marrow is used to repopulate irradiated wild-type mice, intranasal ovalbumin challenge induces reduced TH2 cells (eosinophils, macrophages, and lymphocytes) migration into the bronchoalveolar lavage compared with similarly treated wild-type mice

• however, TH2 cell polarization is normal

decreased susceptibility to type I hypersensitivity reaction ( J:168252 )

• when bone marrow is used to repopulate irradiated wild-type mice, intranasal ovalbumin challenge induces reduced TH2 cells (eosinophils, macrophages, and lymphocytes) migration into the bronchoalveolar lavage and reduced ovalbumin-IgE serum levels compared with similarly treated wild-type mice

increased susceptibility to autoimmune disorder ( J:168252 )

• mice develop symptoms of an auto-inflammatory disease and do not survive beyond 6 to 8 weeks of age

hematopoietic system

decreased IgE level ( J:168252 )

• when bone marrow is used to repopulate irradiated wild-type mice, intranasal ovalbumin challenge induces reduced ovalbumin-IgE serum levels compared with similarly treated wild-type mice

abnormal T-helper 2 physiology ( J:168252 )

• when bone marrow is used to repopulate irradiated wild-type mice, intranasal ovalbumin challenge induces reduced TH2 cells (eosinophils, macrophages, and lymphocytes) migration into the bronchoalveolar lavage compared with similarly treated wild-type mice

• however, TH2 cell polarization is normal