Analysis Tools
mortality/aging
|
• mice die between 2 and 3 weeks of age likely from airway obstruction and asphyxiation
|
respiratory system
|
• mice exhibit large dense patches consisting of infiltrating neutrophils that is not secondary to bacterial infection unlike control mice
• however, treatment with amiloride reduces inflammation
|
|
• mice exhibit decreased lung wet/dry ratio compared with control mice
• however, treatment with amiloride improves lung defects
|
|
• mice exhibit cystic fibrosis-like defects unlike control mice
|
|
• mice exhibit increased nonciliated mucus secreting (mostly goblet) cells in the trachea unlike control mice
|
|
• mice exhibit increased nonciliated mucus secreting (mostly goblet) cells in the trachea unlike control mice
|
|
• airway periciliary liquid layer in the trachea is decreased in height compared to in control mice
|
immune system
|
• mice exhibit large dense patches consisting of infiltrating neutrophils that is not secondary to bacterial infection unlike control mice
• however, treatment with amiloride reduces inflammation
|
