About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezh1tm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:4941012
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ezh1tm1Jnw/Ezh1tm1Jnw Not Specified MGI:4941023
cn2
 		Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0 		involves: 129P2/OlaHsd MGI:4941024


Genotype
MGI:4941023
hm1
Allelic
Composition		 Ezh1tm1Jnw/Ezh1tm1Jnw
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (1 available); any Ezh1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:169295 )
• viable, fertile, and healthy




Genotype
MGI:4941024
cn2
Allelic
Composition		 Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (1 available); any Ezh1 mutation (34 available)
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (72 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells

mortality/aging
neonatal lethality, complete penetrance ( J:169295 )
• mice die within 24 hours of birth

integument
integument phenotype ( J:169295 )
N
• mice do not exhibit skin inflammation
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells
abnormal hair growth ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle
• skin grafts on nude mice remain hairless unlike wild-type grafts
abnormal hair follicle infundibulum morphology ( J:169295 )
• skin grafts exhibit hyperproliferation in the infundibulum compared with wild-type cells
abnormal hair follicle outer root sheath morphology ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation compared with wild-type cells
hair follicle degeneration ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation regardless of stimulation compared with wild-type cells
small hair follicles ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle

behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory