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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezh1tm1Jnw
targeted mutation 1, Thomas Jenuwein
MGI:4941012
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ezh1tm1Jnw/Ezh1tm1Jnw Not Specified MGI:4941023
cn2
 		Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0 		involves: 129P2/OlaHsd MGI:4941024


Genotype
MGI:4941023
hm1
Allelic
Composition		 Ezh1tm1Jnw/Ezh1tm1Jnw
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (1 available); any Ezh1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:169295 )
• viable, fertile, and healthy




Genotype
MGI:4941024
cn2
Allelic
Composition		 Ezh1tm1Jnw/Ezh1tm1Jnw
Ezh2tm1Tara/Ezh2tm1Tara
Tg(KRT14-cre)1Efu/0
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh1tm1Jnw mutation (1 available); any Ezh1 mutation (34 available)
Ezh2tm1Tara mutation (2 available); any Ezh2 mutation (72 available)
Tg(KRT14-cre)1Efu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells

mortality/aging
neonatal lethality, complete penetrance ( J:169295 )
• mice die within 24 hours of birth

integument
integument phenotype ( J:169295 )
N
• mice do not exhibit skin inflammation
increased hair follicle apoptosis ( J:169295 )
• hair follicle cells exhibit increased apoptosis unlike wild-type cells
abnormal hair growth ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle
• skin grafts on nude mice remain hairless unlike wild-type grafts
abnormal hair follicle infundibulum morphology ( J:169295 )
• skin grafts exhibit hyperproliferation in the infundibulum compared with wild-type cells
abnormal hair follicle outer root sheath morphology ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation compared with wild-type cells
hair follicle degeneration ( J:169295 )
• hair follicle stem cells in the lower outer root sheath zone exhibit decreased proliferation regardless of stimulation compared with wild-type cells
small hair follicles ( J:169295 )
• hair follicles in skin grafts arrest in the first growth phase of the hair cycle

behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory