Phenotypes associated with this allele

• Allele Symbol: Trp53^tm1.1Awbr
• Allele Name: targeted mutation 1.1, AW Braithwaite
• Allele ID: MGI:4941040
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trp53^tm1.1Awbr/Trp53^tm1.1Awbr	involves: C57BL/6	MGI:4941049

Genotype
MGI:4941049

hm1

• Allelic Composition: Trp53^tm1.1Awbr/Trp53^tm1.1Awbr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:169434 )

• gamma-irradiated mice exhibit a median survival of 423 days and a maximum survival of 550 compared with similarly treated mice that live beyond 600 days

• however, survival is improved compared with similarly treated Trp53 null mice

neoplasm

increased T cell derived lymphoma incidence ( J:173271 )

• in 56% of mice

increased B cell derived lymphoma incidence ( J:173271 )

• diffuse large B cell lymphoma in 18% of mice

increased follicular lymphoma incidence ( J:169434 )

• following gamma-irradiation

increased histiocytic sarcoma incidence ( J:173271 )

• 5 of 7 mice exhibit malignant fibrous histiocytomas with angiogenesis

increased fibrosarcoma incidence ( J:169434 )

• in one mouse exposed to gamma radiation

increased osteosarcoma incidence ( J:173271 )

• in 6% of mice

increased incidence of tumors by ionizing radiation induction ( J:169434 )

• following gamma-irradiation, most mice develop B cell lymphomas, predominantly follicular lymphoma, composed of incorrectly differentiated B cells unlike wild-type mice

cellular

decreased sensitivity to induced cell death ( J:169434 )

• B cells exposed to amsacrine fail to exhibit an increase in apoptosis compared with similarly treated wild-type cells

decreased cellular sensitivity to gamma-irradiation ( J:169434 )

• thymocytes exposed to gamma-irradiation or the topoisomerase 2 inhibitor amsacrine fail to exhibit an increase in apoptosis above background levels unlike similarly treated wild-type cells

• mice exposed to gamma-irradiation fail to exhibit an increase in apoptosis in the thymus and spleen unlike similarly treated wild-type mice

• however, cell-cycle restriction induced by DNA damage is normal

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

immune system

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased T cell derived lymphoma incidence ( J:173271 )

• in 56% of mice

increased pro-B cell number ( J:169434 )

• in the bone marrow and spleen of aged mice

hematopoietic system

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased T cell derived lymphoma incidence ( J:173271 )

• in 56% of mice

increased pro-B cell number ( J:169434 )

• in the bone marrow and spleen of aged mice

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:169434 )

• gamma-irradiated mice exhibit a median survival of 423 days and a maximum survival of 550 compared with similarly treated mice that live beyond 600 days

• however, survival is improved compared with similarly treated Trp53 null mice

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:173271 )

• following gamma radiation, thymocytes fail to undergo apoptosis unlike wild-type cells

increased T cell derived lymphoma incidence ( J:173271 )

• in 56% of mice

skeleton

increased osteosarcoma incidence ( J:173271 )

• in 6% of mice