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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp1a4tm1Itl
targeted mutation 1, inGenious Targeting Laboratory
MGI:4941050
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp1a4tm1Itl/Atp1a4tm1Itl involves: 129S6/SvEvTac * C57BL/6 MGI:4941051
ht2
 		Atp1a4tm1Itl/Atp1a4+ involves: 129S6/SvEvTac * C57BL/6 MGI:4941052


Genotype
MGI:4941051
hm1
Allelic
Composition		 Atp1a4tm1Itl/Atp1a4tm1Itl
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a4tm1Itl mutation (0 available); any Atp1a4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:169420 )
N
• female mice are fertile
• testes morphology is normal
kinked sperm flagellum ( J:169420 )
• between the mid- and principal piece
impaired sperm capacitation ( J:169420 )
• hyperactivation typical of sperm capacitation is reduced compared with wild-type sperm
impaired fertilization ( J:169420 )
• sperm fail to fertilize oocytes in vitro unlike wild-type sperm
abnormal sperm physiology ( J:169420 )
• sperm lack sodium-potassium ATPase activity compared with wild-type cells
• sperm exhibit altered internal sodium concentration and membrane potential compared with wild-type sperm

cellular
kinked sperm flagellum ( J:169420 )
• between the mid- and principal piece




Genotype
MGI:4941052
ht2
Allelic
Composition		 Atp1a4tm1Itl/Atp1a4+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a4tm1Itl mutation (0 available); any Atp1a4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:169420 )
• partially reduced

cellular
asthenozoospermia ( J:169420 )
• partially reduced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory