cellular
aneuploidy
(
J:169403
)
• in mammary epithelial cells
|
polyploidy
(
J:169403
)
• in mammary epithelial cells
|
• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells
|
neoplasm
• all mice succumb to brain tumors with a latency of 54 weeks
|
endocrine/exocrine glands
• mammary ductal branching is decreased compared to in control mice
|
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice
|
integument
• mammary ductal branching is decreased compared to in control mice
|
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice
|
nervous system
• all mice succumb to brain tumors with a latency of 54 weeks
|