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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm3(myc*S62A)Rcse
targeted mutation 3, Rosalie C Sears
MGI:4941058
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse
Tg(Wap-cre)11738Mam/0
involves: 129 * C57BL/6 * SJL MGI:4941161


Genotype
MGI:4941161
cn1
Allelic
Composition
Gt(ROSA)26Sortm3(myc*S62A)Rcse/Gt(ROSA)26Sortm3(myc*S62A)Rcse
Tg(Wap-cre)11738Mam/0
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3(myc*S62A)Rcse mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Wap-cre)11738Mam mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in mammary epithelial cells
• in mammary epithelial cells
• mammary epithelial cells exhibit increased chromosomal instability with high rates of polyploidy and aneuploidy compared with control cells

neoplasm
• all mice succumb to brain tumors with a latency of 54 weeks

endocrine/exocrine glands
• mammary ductal branching is decreased compared to in control mice
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice

integument
• mammary ductal branching is decreased compared to in control mice
• parous mice exhibit a reduced number of alveoli compared with Gt(ROSA)26Sortm1(myc)Rcse/Gt(ROSA)26Sortm1(myc)Rcse Tg(Wap-cre)11738Mam mice

nervous system
• all mice succumb to brain tumors with a latency of 54 weeks





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory