Phenotypes associated with this allele

• Allele Symbol: Akt3^Nmf350
• Allele Name: neuroscience mutagenesis facility, 350
• Allele ID: MGI:4941186
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt3^Nmf350/Akt3^Nmf350	C57BL/6J-Akt3^Nmf350	MGI:4941199
ht2	Akt3^Nmf350/Akt3^+	C57BL/6J-Akt3^Nmf350	MGI:4941200

Genotype
MGI:4941199

hm1

• Allelic Composition: Akt3^Nmf350/Akt3^Nmf350
• Genetic Background: C57BL/6J-Akt3^Nmf350

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

increased brain size ( J:169028 )

increased brain weight ( J:169028 )

absent corpus callosum ( J:169028 )

• in 1 of 20 mice

enlarged hippocampus ( J:169028 )

abnormal neuron morphology ( J:169028 )

• mice exhibit ectopic neurons in the hilus and molecular layer unlike in wild-type mice

• mice exhibit ectopic proliferating neurons in the hilus compared with wild-type mice

• ectopic neurons are more numerous in younger mice

ectopic cerebellar granule cells ( J:169028 )

• in the hilus

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation

Genotype
MGI:4941200

ht2

• Allelic Composition: Akt3^Nmf350/Akt3⁺
• Genetic Background: C57BL/6J-Akt3^Nmf350

nervous system

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• in response to transcorneal electrical stimulation, mice exhibit generalized, tonic-clonic seizures and maximal tonic hindlimb extension seizures unlike wild-type mice

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation or PTZ treatment

sporadic seizures ( J:169028 )

• after 6 months, mice exhibit spontaneous sporadic seizures unlike wild-type mice

• however, mice do not exhibit interictal epileptic EEG overnight

increased brain size ( J:169028 )

increased brain weight ( J:169028 )

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:169028 )

• induced by PTZ treatment

abnormal seizure response to electrical stimulation ( J:169028 )

• in response to transcorneal electrical stimulation, mice exhibit generalized, tonic-clonic seizures and maximal tonic hindlimb extension seizures unlike wild-type mice

• mice exhibit lower electroconvulsive threshold to generalized seizure compared with wild-type mice

maximal tonic hindlimb extension seizures ( J:169028 )

• in response to transcorneal electrical stimulation

tonic-clonic seizures ( J:169028 )

• in response to transcorneal electrical stimulation or PTZ treatment

sporadic seizures ( J:169028 )

• after 6 months, mice exhibit spontaneous sporadic seizures unlike wild-type mice

• however, mice do not exhibit interictal epileptic EEG overnight