All Phenotypes Adar<tm1Olds> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Adar^tm1Olds
targeted mutation 1, Michael B A Oldstone
MGI:4941203

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adar^tm1Olds/Adar^tm1Olds	involves: 129S/SvEv * C57BL/6J	MGI:4941204
ht2	Adar^em1Stsn/Adar^tm1Olds	involves: 129S/SvEv * C57BL/6J	MGI:7281832
cx3	Adar^em1Stsn/Adar^tm1Olds Rnasel^tm1Slvm/Rnasel^tm1Slvm	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:7281851
cx4	Adar^em1Stsn/Adar^tm1Olds Ifnar1^tm1Agt/Ifnar1^tm1Agt	involves: 129S/SvEv * 129S2/SvPas * C57BL/6J	MGI:7281848
cx5	Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:7281849
cx6	Adar^em1Stsn/Adar^tm1Olds Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J	MGI:7281844
cx7	Adar^em1Stsn/Adar^tm1Olds Dhx58^tm1Itl/Dhx58^tm1Itl	involves: 129S/SvEv * C57BL/6J * C57BL/6NTac	MGI:7281847

Allelic Composition	Adar^tm1Olds/Adar^tm1Olds
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm1Olds mutation (0 available); any Adar mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:169014 )

• mice die at E11 to E12

immune system

increased susceptibility to Orthomyxoviridae infection ( J:169014 )

• mouse embryonic fibroblasts infected with an Orthomyxoviridae Family virus (influenza) exhibit higher titers than similarly treated wild-type cells

• however, response to infection with lymphocytic choriomeningitis virus, vesicular stomatitis virus, or reovirus is normal

increased susceptibility to Paramyxoviridae infection ( J:169014 )

• mouse embryonic fibroblasts infected with Paramyxoviridae Family viruses (measles, Newcastle disease, Sendai, and canine distemper) exhibit higher titers than similarly treated wild-type cells

cellular

abnormal cell physiology ( J:169014 )

• mouse embryonic fibroblasts infected with Paramyxoviridae Family viruses (measles, Newcastle disease, Sendai, and canine distemper) or an Orthomyxoviridae Family virus (influenza) exhibit higher titers than similarly treated wild-type cells

• however, response to infection with lymphocytic choriomeningitis virus, vesicular stomatitis virus, or reovirus is normal

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds
Genetic Background	involves: 129S/SvEv * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Stsn mutation (0 available); any Adar mutation (72 available)
Adar^tm1Olds mutation (0 available); any Adar mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:308678 )

• at weaning

hematopoietic system

abnormal spleen morphology ( J:308678 )

• lymphoid depletion

homeostasis/metabolism

abnormal homeostasis ( J:308678 )

• increased expression of interferon-stimulated genes in cerebellum, kidney and liver

• increased expression of integrated stress response (ISR) genes in kidney and liver

• normal expression of integrated stress response (ISR) genes in cerebellum

increased circulating alkaline phosphatase level ( J:308678 )

decreased circulating serum albumin level ( J:308678 )

immune system

abnormal spleen morphology ( J:308678 )

• lymphoid depletion

liver/biliary system

abnormal liver morphology ( J:308678 )

• extensive microvesicular cytoplasmic vacuolation

mortality/aging

lethality, complete penetrance ( J:308678 )

• no survival beyond ~130 days

renal/urinary system

abnormal renal glomerulus morphology ( J:308678 )

• significant immunoglobulin G (IgG) deposition

expanded mesangial matrix ( J:308678 )

• increasing with age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Aicardi-Goutieres syndrome		DOID:0050629	OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750	J:308678

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Rnasel^tm1Slvm/Rnasel^tm1Slvm
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Ifnar1^tm1Agt/Ifnar1^tm1Agt
Genetic Background	involves: 129S/SvEv * 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

• normal expression of interferon-stimulated genes in kidney

• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

abnormal homeostasis ( J:308678 )

• increased expression of interferon-stimulated genes in cerebellum and liver

• normal expression of interferon-stimulated genes in kidney

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
Genetic Background	involves: 129S/SvEv * 129X1/SvJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

Allelic Composition	Adar^em1Stsn/Adar^tm1Olds Dhx58^tm1Itl/Dhx58^tm1Itl
Genetic Background	involves: 129S/SvEv * C57BL/6J * C57BL/6NTac

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:308678 )

N	• normal weight, weight gain and growth

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

N	• normal expression of interferon-stimulated genes in cerebellum, kidney and liver • normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

mortality/aging

mortality/aging ( J:308678 )

N	• normal survival

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