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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbiatm1.1Smiy
targeted mutation 1.1, Shigeki Miyamoto
MGI:4941306
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbiatm1.1Smiy/Nfkbiatm1.1Smiy B6.129-Nfkbiatm1.1Smiy MGI:4941313
ht2
 		Nfkbiatm1.1Smiy/Nfkbia+ B6.129-Nfkbiatm1.1Smiy MGI:4941314


Genotype
MGI:4941313
hm1
Allelic
Composition		 Nfkbiatm1.1Smiy/Nfkbiatm1.1Smiy
Genetic
Background		 B6.129-Nfkbiatm1.1Smiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1.1Smiy mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
abnormal B cell differentiation ( J:168977 )
• according to reconstitution experiments, B cell defects are hematopoietically cell intrinsic
increased immature B cell number ( J:168977 )
• in the bone marrow
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen
decreased mature B cell number ( J:168977 )
• in the bone marrow
increased pre-B cell number ( J:168977 )
• in the bone marrow
decreased regulatory T cell number ( J:168977 )
• the percent T regulatory cells in the spleen and thymus is decreased compared to in wild-type mice

hematopoietic system
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
abnormal B cell differentiation ( J:168977 )
• according to reconstitution experiments, B cell defects are hematopoietically cell intrinsic
increased immature B cell number ( J:168977 )
• in the bone marrow
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen
decreased mature B cell number ( J:168977 )
• in the bone marrow
increased pre-B cell number ( J:168977 )
• in the bone marrow
decreased regulatory T cell number ( J:168977 )
• the percent T regulatory cells in the spleen and thymus is decreased compared to in wild-type mice

cellular
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation




Genotype
MGI:4941314
ht2
Allelic
Composition		 Nfkbiatm1.1Smiy/Nfkbia+
Genetic
Background		 B6.129-Nfkbiatm1.1Smiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1.1Smiy mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen

hematopoietic system
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/17/2024
MGI 6.24 		The Jackson Laboratory