About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbiatm1.1Smiy
targeted mutation 1.1, Shigeki Miyamoto
MGI:4941306
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbiatm1.1Smiy/Nfkbiatm1.1Smiy B6.129-Nfkbiatm1.1Smiy MGI:4941313
ht2
 		Nfkbiatm1.1Smiy/Nfkbia+ B6.129-Nfkbiatm1.1Smiy MGI:4941314


Genotype
MGI:4941313
hm1
Allelic
Composition		 Nfkbiatm1.1Smiy/Nfkbiatm1.1Smiy
Genetic
Background		 B6.129-Nfkbiatm1.1Smiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1.1Smiy mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
abnormal B cell differentiation ( J:168977 )
• according to reconstitution experiments, B cell defects are hematopoietically cell intrinsic
increased immature B cell number ( J:168977 )
• in the bone marrow
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen
decreased mature B cell number ( J:168977 )
• in the bone marrow
increased pre-B cell number ( J:168977 )
• in the bone marrow
decreased regulatory T cell number ( J:168977 )
• the percent T regulatory cells in the spleen and thymus is decreased compared to in wild-type mice

hematopoietic system
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
abnormal B cell differentiation ( J:168977 )
• according to reconstitution experiments, B cell defects are hematopoietically cell intrinsic
increased immature B cell number ( J:168977 )
• in the bone marrow
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen
decreased mature B cell number ( J:168977 )
• in the bone marrow
increased pre-B cell number ( J:168977 )
• in the bone marrow
decreased regulatory T cell number ( J:168977 )
• the percent T regulatory cells in the spleen and thymus is decreased compared to in wild-type mice

cellular
increased activation-induced B cell apoptosis ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation
decreased B cell proliferation ( J:168977 )
• upon anti-IgM and IL4 or LPS stimulation




Genotype
MGI:4941314
ht2
Allelic
Composition		 Nfkbiatm1.1Smiy/Nfkbia+
Genetic
Background		 B6.129-Nfkbiatm1.1Smiy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbiatm1.1Smiy mutation (1 available); any Nfkbia mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen

hematopoietic system
increased pro-B cell number ( J:168977 )
• in the bone marrow
decreased B cell number ( J:168977 )
• in the spleen




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory