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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rag2tm1.1Desi
targeted mutation 1.1, Stephen Desiderio
MGI:4941315
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rag2tm1.1Desi/Rag2tm1.1Desi involves: 129X1/SvJ * C57BL/6 MGI:4941320
cx2
 		Rag2tm1.1Desi/Rag2tm1.1Desi
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:4941322


Genotype
MGI:4941320
hm1
Allelic
Composition		 Rag2tm1.1Desi/Rag2tm1.1Desi
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1.1Desi mutation (0 available); any Rag2 mutation (119 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal immunoglobulin V(D)J recombination ( J:168974 )
• thymocytes accumulate recombination signal sequence breaks and increased frequency of aberrant V(D)J recombination compared with wild-type cells

immune system
abnormal immunoglobulin V(D)J recombination ( J:168974 )
• thymocytes accumulate recombination signal sequence breaks and increased frequency of aberrant V(D)J recombination compared with wild-type cells




Genotype
MGI:4941322
cx2
Allelic
Composition		 Rag2tm1.1Desi/Rag2tm1.1Desi
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1.1Desi mutation (0 available); any Rag2 mutation (119 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:168974 )
• unlike in Trp53tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:168974 )
• unlike in Trp53tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations

hematopoietic system
increased T cell derived lymphoma incidence ( J:168974 )
• unlike in Trp53tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations

immune system
increased T cell derived lymphoma incidence ( J:168974 )
• unlike in Trp53tm1Tyj homozygotes, T cell derived lymphomas contain less mature CD4-CD8- and CD4-CD8+ intermediate single positive cells and some lymphomas exhibit chromosomal translocations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory