All Phenotypes Rcan2<tm1Ypt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rcan2^tm1Ypt/Rcan2^tm1Ypt	B6.129-Rcan2^tm1Ypt	MGI:4941375
cx2	Lep^ob/Lep^ob Rcan2^tm1Ypt/Rcan2^tm1Ypt	involves: 129 * C57BL/6	MGI:4941374

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:169558 )

• when fed a high fat diet

decreased body size ( J:169558 )

• at 3 weeks of age

decreased body weight ( J:169558 )

• at 22 weeks of age

• at 18 months of age

• whether fed standard chow or a high-fat diet

postnatal growth retardation ( J:169558 )

• up to 5 weeks of age

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:169558 )

• when fed a high fat diet

improved glucose tolerance ( J:169558 )

• in mice fed a high fat diet

increased insulin sensitivity ( J:169558 )

• in mice fed a high fat diet

adipose tissue

decreased epididymal fat pad weight ( J:169558 )

• in mice fed a high fat diet

decreased retroperitoneal fat pad weight ( J:169558 )

• in mice fed a high fat diet

behavior/neurological

decreased food intake ( J:169558 )

• when fed standard chow or a high-fat diet

decreased compensatory feeding amount ( J:169558 )

• after fasting and re-feeding

decreased locomotor activity ( J:169558 )

• at night when fed standard chow

liver/biliary system

decreased liver weight ( J:169558 )

• in mice fed a high fat diet

decreased susceptibility to diet-induced hepatic steatosis ( J:169558 )

• in mice fed a high fat diet

skeleton

short tibia ( J:169558 )

• at 9 months of age on standard chow

limbs/digits/tail

short tibia ( J:169558 )

• at 9 months of age on standard chow

Allelic Composition	Lep^ob/Lep^ob Rcan2^tm1Ypt/Rcan2^tm1Ypt
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lep^ob mutation (5 available); any Lep mutation (21 available)
Rcan2^tm1Ypt mutation (0 available); any Rcan2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased epididymal fat pad weight ( J:169558 )

• compared with Lep^ob homozygotes

decreased retroperitoneal fat pad weight ( J:169558 )

• compared with Lep^ob homozygotes

growth/size/body

decreased body weight ( J:169558 )

• compared with Lep^ob homozygotes

liver/biliary system

decreased liver weight ( J:169558 )

• compared with Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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