Phenotypes associated with this allele

• Allele Symbol: Chrng^{tm2(Chrne)Vwi}
• Allele Name: targeted mutation 2, Veit Witzemann
• Allele ID: MGI:4941453
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrng^tm2(Chrne)Vwi/Chrng^tm2(Chrne)Vwi	involves: C57BL/6	MGI:4941456

Genotype
MGI:4941456

hm1

• Allelic Composition: Chrng^{tm2(Chrne)Vwi}/Chrng^{tm2(Chrne)Vwi}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:169541 )

• likely due to respiratory paralysis

nervous system

abnormal neuromuscular synapse morphology ( J:169541 )

• endplates are scattered in the diaphragm compared with wild-type mice

• muscle fibers exhibit multiple endplates in the diaphragm unlike in wild-type mice

• however, scattered endplate are innervate

abnormal miniature endplate potential ( J:169541 )

• lower frequency at E16 and E18

behavior/neurological

trunk curl ( J:169541 )

no spontaneous movement ( J:169541 )

pigmentation

abnormal skin pigmentation ( J:169541 )

muscle

thin diaphragm muscle ( J:169541 )

• at E16 and E18

embryo

decreased embryo size ( J:169541 )

growth/size/body

decreased embryo size ( J:169541 )

integument

abnormal skin pigmentation ( J:169541 )