All Phenotypes Srgap3<tm1Ssod> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Srgap3^tm1Ssod
targeted mutation 1, Scott H Soderling
MGI:4941458

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Srgap3^tm1Ssod/Srgap3^tm1Ssod	Not Specified	MGI:4941463
cn2	Srgap3^tm1Ssod/Srgap3^tm1.1Ssod Tg(Thy1-cre/ERT2,-EYFP)VGfng/0	involves: C57BL/6 * SJL	MGI:4941466
cn3	Srgap3^tm1Ssod/Srgap3^tm1Ssod Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:4941467

Allelic Composition	Srgap3^tm1Ssod/Srgap3^tm1Ssod
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3^tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron morphology ( J:169533 )

• following transfection with GFP-cre at DIV9, neurons exhibit a reduction in dendritic filopodia compared with wild-type mice

abnormal dendritic spine morphology ( J:169533 )

• following transfection with GFP-cre at DIV5, spine density is reduced with a reduction in density of mushroom-shaped and thin spines compared to in wild-type mice

• however, spine density is normal when transfection at DIV9

Allelic Composition	Srgap3^tm1Ssod/Srgap3^tm1.1Ssod Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3^tm1.1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Srgap3^tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Thy1-cre/ERT2,-EYFP)VGfng mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:169533 )

N	• tamoxifen-treated mice exhibit normal spine density

Allelic Composition	Srgap3^tm1Ssod/Srgap3^tm1Ssod Tg(Nes-cre)1Kln/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3^tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:169533 )

• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice

impaired passive avoidance behavior ( J:169533 )

• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice

impaired long-term object recognition memory ( J:169533 )

• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice

abnormal long-term spatial reference memory ( J:169533 )

• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice

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