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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srgap3tm1Ssod
targeted mutation 1, Scott H Soderling
MGI:4941458
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Srgap3tm1Ssod/Srgap3tm1Ssod Not Specified MGI:4941463
cn2
 		Srgap3tm1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0 		involves: C57BL/6 * SJL MGI:4941466
cn3
 		Srgap3tm1Ssod/Srgap3tm1Ssod
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:4941467


Genotype
MGI:4941463
cn1
Allelic
Composition		 Srgap3tm1Ssod/Srgap3tm1Ssod
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:169533 )
• following transfection with GFP-cre at DIV9, neurons exhibit a reduction in dendritic filopodia compared with wild-type mice
abnormal dendritic spine morphology ( J:169533 )
• following transfection with GFP-cre at DIV5, spine density is reduced with a reduction in density of mushroom-shaped and thin spines compared to in wild-type mice
• however, spine density is normal when transfection at DIV9




Genotype
MGI:4941466
cn2
Allelic
Composition		 Srgap3tm1Ssod/Srgap3tm1.1Ssod
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1.1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Srgap3tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Thy1-cre/ERT2,-EYFP)VGfng mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:169533 )
N
• tamoxifen-treated mice exhibit normal spine density




Genotype
MGI:4941467
cn3
Allelic
Composition		 Srgap3tm1Ssod/Srgap3tm1Ssod
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Srgap3tm1Ssod mutation (0 available); any Srgap3 mutation (62 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal learning/memory/conditioning ( J:169533 )
• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice
impaired passive avoidance behavior ( J:169533 )
• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice
impaired long-term object recognition memory ( J:169533 )
• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice
abnormal long-term spatial reference memory ( J:169533 )
• mice exhibit impaired long term memory in a novel recognition, water maze, and passive avoidance assay compared with wild-type mice




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory