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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Thy1-EGFP)#Jrs
transgene insertion, Joshua R Sanes
MGI:4941461
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tshz3tm2.1Lafa/Tshz3tm2.1Lafa
Tg(Camk2a-cre)2Gsc/0
Tg(Thy1-EGFP)#Jrs/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N MGI:7261399
cx2
 		Mecp2tm1.1Joez/Y
Tg(Thy1-EGFP)#Jrs/0 		involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:5310737
cx3
 		Pde4benu1H/Pde4benu1H
Tg(Thy1-EGFP)#Jrs/0 		involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA MGI:5648931


Genotype
MGI:7261399
cn1
Allelic
Composition		 Tshz3tm2.1Lafa/Tshz3tm2.1Lafa
Tg(Camk2a-cre)2Gsc/0
Tg(Thy1-EGFP)#Jrs/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Camk2a-cre)2Gsc mutation (2 available)
Tg(Thy1-EGFP)#Jrs mutation (0 available)
Tshz3tm2.1Lafa mutation (0 available); any Tshz3 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dendritic spine density ( J:294534 )
• mice show reduced spine density in layer 5 cortical projection neurons
• however, no major changes in overall cortical projection neurons morphology and projections are seen




Genotype
MGI:5310737
cx2
Allelic
Composition		 Mecp2tm1.1Joez/Y
Tg(Thy1-EGFP)#Jrs/0
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1.1Joez mutation (1 available); any Mecp2 mutation (41 available)
Tg(Thy1-EGFP)#Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampus pyramidal cell morphology ( J:181311 )
• at P30 and P90, hippocampal CA1 pyramidal neurons exhibit decreased soma size compared with control cells




Genotype
MGI:5648931
cx3
Allelic
Composition		 Pde4benu1H/Pde4benu1H
Tg(Thy1-EGFP)#Jrs/0
Genetic
Background		 involves: BALB/cAnN * C3H/HeH * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pde4benu1H mutation (2 available); any Pde4b mutation (55 available)
Tg(Thy1-EGFP)#Jrs mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased dendritic spine density ( J:223217 )
• increased spine density in the hippocampus and lateral amygdala




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory