Phenotypes associated with this allele

• Allele Symbol: Tafa5^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4941495
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tafa5^tm1a(KOMP)Wtsi/Tafa5^+ Tg(APPswe,PSEN1dE9)85Dbo/0	B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo Tafa5^tm1a(KOMP)Wtsi	MGI:8161059

Genotype
MGI:8161059

cx1

• Allelic Composition: Tafa5^{tm1a(KOMP)Wtsi}/Tafa5⁺; Tg(APPswe,PSEN1dE9)85Dbo/0
• Genetic Background: B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo Tafa5^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:360724 )

• mice exhibit an extended lifespan compared to Tg(APPswe,PSEN1dE9)85Dbo/0 mice, with survival rate beginning to decline at approximately 14 weeks of age compared to 8 weeks of age in Tg(APPswe,PSEN1dE9)85Dbo/0 mice and 65% of mice survive to 45 weeks compared to 40% of Tg(APPswe,PSEN1dE9)85Dbo/0 mice

nervous system

amyloid beta deposits ( J:360724 )

• mice exhibit a lower amyloid beta plaque density than single Tg(APPswe,PSEN1dE9)85Dbo/0 mice

homeostasis/metabolism

amyloid beta deposits ( J:360724 )

• mice exhibit a lower amyloid beta plaque density than single Tg(APPswe,PSEN1dE9)85Dbo/0 mice